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Human coronaviruses, first characterized in the 1960s, are responsible for a substantial proportion of upper respiratory tract infections in children. Since 2003, at least 5 new human coronaviruses have been identified, including the severe acute respiratory syndrome coronavirus, which caused significant morbidity and mortality. NL63, representing a group of newly identified group I coronaviruses that includes NL and the New Haven coronavirus, has been identified worldwide. These viruses are associated with both upper and lower respiratory tract disease and are likely common human pathogens. The global distribution of a newly identified group II coronavirus, HKU1, has not yet been established. Coronavirology has advanced significantly in the past few years. The SARS epidemic put the animal coronaviruses in the spotlight. The background and history relative to this important and expanding research area are reviewed here.
Virus corona manusia, yang pertama kali dicirikan pada 1960-an, bertanggung jawab atas sebagian besar infeksi saluran pernapasan atas pada anak-anak. Sejak tahun 2003, setidaknya 5 coronavirus manusia baru telah diidentifikasi, termasuk coronavirus sindrom pernafasan akut yang parah, yang menyebabkan morbiditas dan mortalitas yang signifikan. NL63, mewakili kelompok koronavirus grup I yang baru diidentifikasi yang mencakup NL dan coronavirus New Haven, telah diidentifikasi di seluruh dunia. Virus-virus ini dikaitkan dengan penyakit saluran pernapasan bagian atas dan bawah dan kemungkinan merupakan patogen manusia yang umum. Distribusi global coronavirus kelompok II yang baru diidentifikasi, HKU1, belum ditetapkan. Coronavirology telah meningkat secara signifikan dalam beberapa tahun terakhir. Epidemi SARS menempatkan virus hewan korona dalam sorotan. Latar belakang dan sejarah relatif terhadap bidang penelitian penting dan berkembang ini ditinjau di sini.
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